Molecular pathogenesis of endometrial intraepithelial neoplasia: Precursor to endometrial cancers
نویسندگان
چکیده
منابع مشابه
Endometrial Intraepithelial Neoplasia
Endometrial hyperplasia is of clinical significance because it is often a precursor lesion to adenocarcinoma of the endometrium. Making the distinction between hyperplasia and true precancerous lesions or true neoplasia has significant clinical effect because their differing cancer risks must be matched with an appropriate intervention to avoid undertreatment or overtreatment. Pathologic diagno...
متن کاملMolecular pathogenesis of endometrial cancer
Introduction. Genetic changes which cause endometrial cancer may be discovered by simple comparison of tumor with normal tissues, and correlating clinicopathologic with genotypic features. More difficult is the specific elaboration of those interacting events which may transpire in a particular sequence during a protracted interval of carcinogenesis. A small burden of premalignant cells makes t...
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In this article, the authors briefly review the historical evolution of the various putative precursor lesions for Type II endometrial cancers, with an emphasis on the newly defined "Endometrial Glandular Dysplasia (EmGD)". The evidentiary basis for delineating serous EmGD as the most probable precursor lesions to endometrial serous carcinoma is reviewed in detail. An argument is advanced for t...
متن کاملGenetics of Endometrial Cancers
Endometrial cancers exhibit a different mechanism of tumorigenesis and progression depending on histopathological and clinical types. The most frequently altered gene in estrogen-dependent endometrioid endometrial carcinoma tumors is PTEN. Microsatellite instability is another important genetic event in this type of tumor. In contrast, p53 mutations or Her2/neu overexpression are more frequent ...
متن کاملComparison of WHO and endometrial intraepithelial neoplasia classifications in predicting the presence of coexistent malignancy in endometrial hyperplasia.
OBJECTIVE The most commonly used classification system for endometrial hyperplasia is the World Health Organization system which is based on subjective criteria. Another classification system is endometrial intraepithelial neoplasia (EIN) system which uses diagnostic criteria including cytological demarcation, crowded gland architecture, minimum size of 1 mm, and careful exclusion of mimics, an...
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ژورنال
عنوان ژورنال: Gynecologic Oncology
سال: 2016
ISSN: 0090-8258
DOI: 10.1016/j.ygyno.2016.04.211